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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis

Fig. 3

FTY720 treatment alters the total cell number and ratio of lymphocyte populations in the draining lymph nodes (LNs) of type II collagen–immunized mice. Cells were recovered from draining LNs after immunization and nine treatments with FTY720 as described in the Fig. 1 legend. The number of cells in the LNs of FTY720-treated mice was significantly lower than the number found in the LNs of controls (a). The ratios of B-cell and T-cell subpopulations in the LNs (b and c) were statistically different between FTY720-treated and control mice, although the differences were significantly less than the differences observed in the peripheral blood. Antibody staining, measurement of cell numbers, and data analysis were performed as described in the Fig. 2 legend. Closed stars indicate statistically significant differences (p < 0.05). Open bars indicate 1.0 mg/kg FTY720 treatment, and closed bars represent vehicle control. Error bars indicate standard deviation

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Arthritis Research & Therapy

ISSN: 1478-6362

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