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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: In vitro eradication of citrullinated protein specific B-lymphocytes of rheumatoid arthritis patients by targeted bifunctional nanoparticles

Fig. 2

β60-74Cit peptide-specific antibody secretion of purified B cells from healthy donors and RA patients. B cells were cultured for 5 days in the presence or absence of 7.5 μg/ml CpG and 1.5 ng/ml BAFF a Antibody reactivities in the supernatants against β60-74Cit (filled symbols) and β60-74Arg (open symbols) peptides were detected by ELISA. Individual data points of unstimulated b and stimulated c samples are shown. The ELISA ratios of serum samples from the same donors were between 6 and 14. n healthy = 3, n RA = 5. The data were analyzed with the paired t test, means ± SD are shown (**p <0.01, ***p <0.001). OD optical density, RA rheumatoid arthritis

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