Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy

Fig. 3

Higher synovial expression of TNFα-induced transcripts is associated with overall absence of response to therapy in early rheumatoid arthritis (RA). a Baseline synovial gene expression profiles were compared in poor versus good responders to either tocilizumab or methotrexate therapy at 3 months (4 non-responders versus 9 good responders), and at 6 months (4 non-responders versus 15 good responders). The radar plots indicate how transcripts over-expressed in poor responders (p <0.05, >1.5-fold change in gene expression) are influenced by tocilizumab in synovial biopsies, and by TNFα in cultured monocytes and fibroblast-like synoviocytes (FLS). INV inverse (a negative effect of tocilizumab appears as positive and suggests a positive effect of IL6). b Fold changes in the expression of GADD45B and PDE4D encoding probe sets obtained from HGU133 Plus2.0 transcriptomic data generated in TNFα-stimulated versus non-stimulated monocytes (n = 3) and FLS (n = 3). Box plots represent minimum, maximum and median log2 (fold changes) compared to non-stimulated cells. c Typical GADD45B and PDE4D immunostaining pictures (original magnification × 400) obtained in early RA synovial biopsies, illustrative of marked inter-individual variations in protein expression

Back to article page