Fig. 1

Regions demonstrating significant or borderline significant association with anti-TNF response. The regional plots show three regions with borderline significant association (p <1×10⁻⁶) at 6q15 (top row), 6q27 (middle row) and 10q25.3 (bottom row), based on results from all patients (n = 444) and generalized estimating equations (GEE) models using anti-TNF response at two time points, i.e., 3 and 6 months (left panels). Association results at the same genomic regions are shown for models using anti-TNF response at a single time point only: 6 months (middle panels) and 3 months (right panels). Note: at 6 months, another single nucleotide polymorphism (SNP) in linkage disequilibrium with rs284515 the 6q15 locus (i.e., rs284511) was significantly associated with response at 6 months (change in Disease Activity Score at 6 months, ΔDAS-6); this SNP was not associated at 3 months, and was borderline significant in the GEE model. Chr chromosome