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Table 4 SNPs showing significant or borderline significant association in the cross-sectional analyses or in the GEE model

From: A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis

     

Model 1

Model 2

GEE model

SNP

Chr

Position (bp)

Minor allele

MAF

Phenotype: ΔDAS-3

Phenotype: ΔDAS-6

Phenotype: ΔDAS-3 and ΔDAS-6

N

β

P

N

β

P

N

β

P

rs284511

6

91,208,542

C

0.33

440

0.16

0.01

421

0.41

2.5×10−8

443

0.28

1.5×10−6

rs284515

6

91,208,828

G

0.17

438

0.35

5.6×10−5

419

0.36

1.1×10−4

443

0.35

6.6×10−7

rs75908454

6

169,970,623

C

0.10

440

0.36

0.0007

421

0.49

5.5×10−5

443

0.42

6.3×10−7

rs1679568

10

117,817,551

A

0.15

434

0.27

0.002

415

0.44

5.3×10−6

437

0.35

8.1×10−7

  1. Association results from cross-sectional (models 1 and 2) and longitudinal (generalized estimating equations (GEE) model) analyses - for single nucleotide polymorphisms (SNPs) within regions showing borderline significant association with the GEE model. MAF minor allele frequency ΔDAS-3 and ΔDAS-6, change in Disease Activity Scores based on 28 joint counts (from baseline) at 3 months and 6 months, Chr chromosome
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Arthritis Research & Therapy

ISSN: 1478-6362

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