TY - JOUR AU - TenBroek, Erica M. AU - Yunker, Laurie AU - Nies, Mae Foster AU - Bendele, Alison M. PY - 2016 DA - 2016/01/21 TI - Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat JO - Arthritis Research & Therapy SP - 24 VL - 18 IS - 1 AB - As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block activation of inflammation through nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), subchondral bone changes through receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclastogenesis, and proteolytic degradation through matrix metalloproteinase (MMP)-13 activity. Candidates with low toxicity and predicted efficacy were further examined using either of two widely accepted models of OA joint degeneration in the rat: the monoiodoacetic acid (MIA) model or the medial meniscal tear/medial collateral ligament tear (MMT/MCLT) model. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-016-0921-5 DO - 10.1186/s13075-016-0921-5 ID - TenBroek2016 ER -