Drug | Test range (μM) | Overlapping effective and nontoxic rangea (μM) | NF-κB | MMP-13 | Bone | Tested in vivo |
---|---|---|---|---|---|---|
Alendronate | 0.625–40 | Bone control | N/A | NE | 1.25 and 20 μΜb | MMT/MCLT |
Amrinone | 0.625–80 | 80 | NE | 80 | NE | No |
Ascomycin | 0.01–40 | 1.25–40 | E | NE | E | TBD |
BAY-117082 | 0.188–192 | 6–192 | NE | E | E | Proprietary |
BMS-345541 | 0.24–15.6 | 0.244 | NE | E | E | Proprietary |
Boswellic acid | 0.61–680 | 40–680 | E | E | E | Purity an issue |
Clonidine | 0.156–100 | 10–100 | NE | NE | E | MMT/MCLT and MIA |
CORM-2 | 0.625–40 | 20–40+ | N/A | E | E | Proprietary |
Curcumin | 0.84–108 | 13.5–54 | E | E | E | MMT/MCLT and MIA |
Curcumin-14 | 1.25–80 | 2.5–10 | E | E | NE | TBD |
Diacerein | 1.5–217 | Toxic to chondrocytes | E | E | E | Toxicity and purity issues |
EGCG | 0.688–44 | 5.5–44 | E | E | NE | Purity an issue |
Fluocinolonec | 0.010–100 | 3.1–100 | E | E | E | MMT/MCLT and MIA |
GM6001 | 0.33–25 | NA | NA | 25 | NE | No |
NF-κB activation inhibitor IV | 0.156–10 | NA | 7.7 | NE | N/A | No |
IKK inhibitor Vd (IMMD-0354) | 0.025–26 | 1.625–26 |  | E | E | Cost-prohibitive/proprietary |
IKK inhibitor VI | 0.028–15.2 | 0.24–15.2 | E | E | E | Cost-prohibitive/proprietary |
IKK inhibitor VIII (ACHP) | 0.25–16 | 4 (toxicity to synovial cells) | N/A | E | E | Cost-prohibitive/proprietary |
Meloxicam | 0.125–32 | 16–32 | E | NE | NE | MIA |
Pimecrolimus (ELIDEL; Meda Pharma, Luxembourg) | 0.625–40 | 2.5–20 | E | NE | E | TBD |
Resveratrol | 3.125–200 | 6.25–200 | NE | E | E | TBD |
Rhein | 0.625– 40 | N/A | NE | E | NE | Lack of potency |
SC514 | 0.125–32 | NE in nontoxic range | NE | NE | NE | Proprietary |
Sulfasalazined | 12.5–1600 | 150–1600 |  | E | E | Lack of potency |
Sulindac | 4.35–280 | 280 | E | E | E | Lack of potency |
Tacrolimuse (FK506) | 0.813–100 | 50 | E | E | E | MMT/MCLT and MIA |
Tranilast | 0.125–8 | 1–8 | NE | E | E | MIA |
Triamcinolone acetonide | 0.7–2000 | 250–500 | E | E | E | Aristospan (TH) tested instead |
Triamcinolone hexacetonidee | 3.125–3750 | 62.5–3750 | E | E | E | MMT/MCLT and MIA |
Withaferin Af | 0.25–17 | 4.25–17 | E | E | E | MMT/MCLT model |