Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration

Table 1 Agreement between properties of left and right knees of donors for overall joint grade, and hSF concentrations of protein, hyaluronan, and hyaluronan in molecular weight ranges of 2.5–7 MDa, 1–2.5 MDa, 0.5–1 MDa, and 0.03–0.25 MDa

Measure	Mean ± SD	Slope	Intercept	R²	p	n
Overall joint grade	65 ± 14	0.89 ± 0.07	5 ± 4	0.94	0.5	18
c_Pro	17 ± 8 mg/ml	1.02 ± 0.06	0.1 ± 1.0 mg/ml	0.95	0.45	18
c_HA	2.2 ± 1.6 mg/ml	1.0 ± 0.2	0.2 ± 0.4 mg/ml	0.67	0.74	15
c_{HA(2.5–7MDa)}	1.6 ± 1.2 mg/ml	1.0 ± 0.1	0.0 ± 0.3 mg/ml	0.65	0.51	15
c_{HA(1–2.5MDa)}	0.4 ± 0.4 mg/ml	0.9 ± 0.2	0.03 ± 0.06 mg/ml	0.69	0.88	15
c_{HA(0.5–1MDa)}	0.05 ± 0.07 mg/ml	0.6 ± 0.3	0.01 ± 0.01 mg/ml	0.65	0.27	15
c_{HA(0.03–0.5MDa)}	0.02 ± 0.03 mg/ml	1.1 ± 0.2	0.013 ± 0.007 mg/ml	0.88	0.04	15

The mean and standard deviation (SD) of donor averaged left and right values, slope (mean ± standard error of the mean (SEM)), intercept (mean ± SEM), and correlation coefficient (R²) from reduced major axis regression, p-value from paired t-tests and number of samples (n) are shown. C _Pro Concentration of protein, c _HA Concentration of hyaluronan

ISSN: 1478-6362