Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients

Table 2 Association between the investigated genotypes in SSc-versus-control comparisons in the discovery cohort

SNP	Gene	Minor allele^*	MAF (case)^**	OR (95 % CI)	p value
rs2736100	TERT	T	0.50	1.04 (0.95; 1.13)^†	0.393
rs2076295	DSP	G	0.44	0.96 (0.88; 1.05)^†	0.387
rs4727443	AZGP1	A	0.41	1.03 (0.95; 1.13)^†	0.487
rs7934606	MUC2	A	0.41	1.08 (0.99; 1.18)^†	0.084
rs2034650	IVD	G	0.49	1.03 (0.95; 1.13)^†	0.458
rs1981997	MAPT	A	0.22	0.97 (0.88; 1.08)^†	0.636
rs12610495	DPP9	G	0.28	1.00 (0.91; 1.10)^†	0.967
rs6793295	*LRRC34*	C	0.29	1.14 (1.03; 1.25) ^†	0.009
rs2609255	FAM13A	G	0.22	1.01 (0.91; 1.12)^†	0.851
rs11191865	*OBFC1*	G	0.52	1.09 (1.00; 1.19) ^†	0.043
rs1278769	ATP11A	A	0.24	0.95 (0.86; 1.06)^†	0.365
rs1379326	CSMD1	G	0.26	0.86 (0.69; 1.08)^‡	0.199
rs17690703	SPPL2C	T	0.26	1.03 (0.95; 1.11)	0.546

Gene names: TERT: telomerase reverse transcriptase; DSP: desmoplakin; AZGP1: alpha-2-glycoprotein 1, zinc-binding; MUC2: mucin 2; IVD: isovaleryl-CoA dehydrogenase; MAPT: microtubule-associated protein tau; DPP9: dipeptidyl-peptidase 9; LRRC34: leucine-rich repeat-containing 34; FAMI3A: family with sequence similarity 13, member A; OBFC1: oligonucleotide/oligosaccharide-binding fold containing 1; ATP11A: ATPase, class VI, type 11A; CSMD1: CUB and Sushi multiple domains 1; SPPL2C: signal peptide peptidase-like 2C
SSc systemic sclerosis, SNP single nucleotide polymorphism, MAF minor allele frequency
^*The minor allele is defined as the minor allele in the combined case and control group; ^**MAF is defined as the minor allele frequency in cases and controls; ^†Odds ratio for the minor allele in the additive model; ^‡Odds ratio based on the recessive model

ISSN: 1478-6362