Table 6 Association analysis of investigated genotypes in SSc versus control comparison as well as FVC% in the replication and combined cohorts

Replication

rs2076295 (G)^†

DSP

0.93 (0.82; 1.05)

0.252

0.32 (-1.49; 2.13)

0.729

0.39 (-1.40; 2.17)

0.671

rs1981997 (A) ^†

MAPT

0.79 (0.68; 0.91)

0.002

0.15 (-2.05; 2.35)

0.894

−0.01 (-2.17; 2.15)

0.994

rs6793295 (C)^†

LRRC34

1.06 (0.92; 1.21)

0.435

−0.54 (-2.53;1.45)

0.593

−0.55 (-2.51; 1.41)

0.581

rs11191865 (G)^†

OBFC1

0.90 (0.80; 1.01)

0.093

−0.34 (-2.11; 1.44)

0.710

−0.30 (-2.05; 1.45)

0.736

rs17690703 (T) ^†

SPPL2C

0.64 (0.49; 0.83)

0.001

2.20 (-1.38; 5.78)

0.227

3.11 (-0.45; 6.66)

0.086

Combined

rs2076295 (G)^†

DSP

0.95 (0.89; 1.02)

0.171

−1.02 (-3.58; 1.54)

0.579

−1.07 (-3.94; 1.80)

0.079

rs1981997 (A)^†

MAPT

0.89 (0.78; 1.02)

0.091

1.26 (-0.81; 3.32)

0.445

1.59 (-1.56; 4.74)

0.503

rs6793295 (C) ^†

LRRC34

1.11 (1.03; 1.20)

0.010

−0.50 (-1.80; 0.81)

0.590

−0.81 (-2.12; 0.50)

0.440

rs11191865 (G)^†

OBFC1

1.01 (0.90; 1.13)

0.912

−0.55 (-1.72; 0.61)

0.524

−0.13 (-1.30; 1.04)

0.868

rs17690703 (T) ^†

SPPL2C

1.04 (0.97; 1.13)

0.221

2.32 (0.68; 3.96)

0.006

−1.03 (-4.67; 2.60)

0.575