Fig. 3

Analysis of α-SMA positive blood vessels in arthritic and nonarthritic WT and M3R^−/− mice. a–g Immunohistochemical staining for α-SMA in knee joints of male WT-LPS (a, e), M3R^−/−-LPS (b, f), WT-CAIA (c) and M3R^−/−-CAIA (d, g) mice. Original magnification: 200× (a–d) and 1000× (e–g). h Histopathological score for α-SMA staining. Data are given as mean histopathological score ± SEM. *P < 0.05 CAIA vs. respective LPS control. CAIA collagen antibody-induced arthritis, LPS lipopolysaccharide, M3R M3 muscarinic acetylcholine receptor, WT wild-type, α-SMA alpha-smooth muscle actin