From: Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis
Score | Synovial membrane | Cartilage | Bone | α-SMA |
---|---|---|---|---|
0 | No changes | No changes | No changes | Few blood vessels, none with thickened walls |
1 | >2 cell layers, moderate immune cell infiltration | Erosion in parts of cartilage surface | Bone remodeling only close to the joint capsule | Few blood vessels, few with thickened walls |
2 | >5 cell layers, strong immune cell infiltration, starting pannus formation | Erosion of cartilage surface, cartilage destruction | Bone remodeling also in deeper parts reaching epiphyseal plate | Increased number of blood vessels, some of them with thickened walls |
3 | Like score 2 + pannus formation + more blood vessels | Like score 2 + cartilage covered by connective tissue | Like score 2 + bone degradation | Many blood vessels, most of them (more than 50 %) with thickened walls |