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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model

Fig. 1

Inflammation in delayed-type hypersensitivity arthritis (DTHA) is accompanied by periarticular pannus and subchondral granulation tissue formation. DTHA was induced by intradermal immunization with methylated bovine serum albumin (mBSA) in complete Freund’s adjuvant at the tail base on day −7, followed by intravenous administration of a cocktail of collagen II antibodies on day −4 and footpad challenge with mBSA in phosphate-buffered saline (PBS; right paw) or PBS (left paw) only on day 0. a Paw swelling of the mBSA-challenged right hind paw and the PBS-challenged left paw at indicated time points after DTHA induction (mean ± standard error of the mean, n = 6–16). b Representative examples of hematoxylin and eosin (H&E)-stained tissue sections (original magnification, ×50) of the mBSA-challenged paw (days 5, 10, and 20) and the PBS-challenged paw (day 20). p periarticular pannus, i inflammation, gt subchondral granulation tissue. c Histopathological scoring of inflammation, extraarticular pannus, and subchondral granulation tissue at indicated time points after arthritis induction by evaluation of H&E-stained tissue sections.

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Arthritis Research & Therapy

ISSN: 1478-6362

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