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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model

Fig. 2

Inflammation in delayed-type hypersensitivity arthritis (DTHA) is accompanied by early cartilage damage and bone resorption that precedes new bone formation. a Representative examples of Safranin O/Fast Green and collagen type X (COLX)- and osteocalcin (OC)-stained tissue sections of DTHA or control [phosphate-buffered saline (PBS)] paws at indicated time points. c cartilage, b bone, i inflammation, bm bone marrow, nc new cartilage, nb new bone. Safranin O/Fast Green original magnification × 100, COLX and OC original magnification × 200. b Histological scores of cartilage damage and bone resorption performed on Safranin O/Fast Green–stained tissue sections and of new bone formation performed on COLX- and OC-stained sections (n = 10 per time point). c Assessment of endochondral or direct bone formation or both types in tissue sections of methylated bovine serum albumin (mBSA)-challenged paws at indicated time points assessed on COLX- and OC-stained tissue sections.

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Arthritis Research & Therapy

ISSN: 1478-6362

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