Fig. 3From: Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) modelOsteoclasts are located at the edges of the periarticular and subchondral granulation tissue and at vascular channels at apophyseal sites. Tissue sections of methylated bovine serum albumin (mBSA)-challenged paws from day 5, day 10, and day 20 and of phosphate-buffered saline (PBS)-treated control paws from day 10 were stained for tartrate-resistant acid phosphatase. One representative example at × 100 original magnification (left panels) and × 200 original magnification (right panels) of indicated regions of interest is shown. Black arrowheads indicate osteoclasts, and white arrow indicates vascular channels.Back to article page