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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model

Fig. 3

Osteoclasts are located at the edges of the periarticular and subchondral granulation tissue and at vascular channels at apophyseal sites. Tissue sections of methylated bovine serum albumin (mBSA)-challenged paws from day 5, day 10, and day 20 and of phosphate-buffered saline (PBS)-treated control paws from day 10 were stained for tartrate-resistant acid phosphatase. One representative example at × 100 original magnification (left panels) and × 200 original magnification (right panels) of indicated regions of interest is shown. Black arrowheads indicate osteoclasts, and white arrow indicates vascular channels.

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