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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Changes in resting state functional connectivity after repetitive transcranial direct current stimulation applied to motor cortex in fibromyalgia patients

Fig. 6

Summary of results. Stronger corticothalamic FC and FC between regions with high densities of opioid receptors at baseline predicted a better clinical response across the entire study. Changes in FC were observed after sham transcranial direct current stimulation (tDCS), which could be attributed to placebo analgesia or regression to the mean. Real tDCS caused some distinct long-lasting changes in FC (compared with sham) and may have relieved pain via the inhibition of thalamic activity and subsequent decreases in FC, both of which could have been caused by the release of endogenous opioids. M1 primary motor cortex, S1 primary somatosensory cortex, VL ventral lateral, VPL ventral posterolateral, Ant Ins anterior insula, PAG periaqueductal gray, Post Ins posterior insula, Amyg amygdala, Precun precuneus, SMA supplemental motor area, mPFC medial prefrontal cortex, Cer cerebellum, FC functional connectivity

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