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Table 5 Multivariate analysis of biomarkers and their interactions to predict radiographic and erosive progression

From: Serum levels of 14-3-3η protein supplement C-reactive protein and rheumatoid arthritis-associated antibodies to predict clinical and radiographic outcomes in a prospective cohort of patients with recent-onset inflammatory polyarthritis

GLM ΔSvH estimate (SE) ΔErosion estimate (SE)
 14-3-3η 0.098 (0.045) * 0.088 (0.033) **
 Age (years) 0.106 (0.017) *** 0.056 (0.013) ***
 Anti-CCP2 0.003 (0.002) 0.001 (0.002)
 RF 0.000 (0.001) 0.000 (0.001)
 Anti-Sa positive 3.104 (0.747) *** 2.878 (0.543) ***
 CRP 0.032 (0.008) *** 0.025 (0.006) ***
GEE ΔSvH ≥5 RR (95 % CI) ΔErosion ≥5 RR (95 % CI)
 14-3-3η ≥0.50 ng/ml 2.176 (1.193–3.970) * 2.276 (1.448–3.577) ***
 Age ≥65 years 2.680 (1.859–3.864) *** 2.751 (1.760–4.301) ***
 Anti-CCP2-positive 1.048 (0.696–1.577) 1.134 (0.635–2.025)
 RF-positive 1.191 (0.739–1.921) 1.689 (1.042–2.738) *
 Anti-Sa-positive 1.537 (0.708–3.335) 2.507 (1.348–4.659) **
 CRP >8.0 mg/L 1.425 (1.112–1.826) ** 1.834 (1.304–2.578) ***
 14-3-3η ≥0.50 * age ≥65 years 0.677 (0.396–1.156) Not included
 14-3-3η ≥0.50 * RF-positive 0.724 (0.386–1.358) 0.552 (0.310–0.983) *
 14-3-3η ≥0.50 * anti-Sa positive 0.898 (0.470–1.717) 0.400 (0.204–0.786) **
 Age ≥65 * anti-CCP2 positive 0.899 (0.507–1.596) 0.692 (0.351–1.365)
 Age ≥65 * anti-Sa positive 0.593 (0.345–1.017) Not included
 RF-positive * anti-Sa positive 1.256 (0.607–2.597) Not included
 Anti-CCP2-positive * anti-Sa positive Not included 0.856 (0.424–1.728)
  1. Age, gender, 14-3-3η, C-reactive protein (CRP) and rheumatoid arthritis-associated rheumatoid factor (RF), antibodies against citrullinated peptides, second generation (anti-CCP2) and anti-Sa antibodies, and all their interaction terms were included in multivariate generalized linear model (GLM) or general estimating equation (GEE) analysis. Only the models with the lowest Akaike information criterion (AIC) or quasi-AIC are presented. *p <0.05, **p <0.01, ***p <0.001. SE standard error ΔSvH progression in the total Sharp score modified by van der Heijde, ΔErosion progression in the erosion component of the Sharp score modified by van der Heijde. Not includedvariable excluded from the final model