Table 5 Multivariate analysis of biomarkers and their interactions to predict radiographic and erosive progression

 14-3-3η

0.098 (0.045) *

0.088 (0.033) **

 Age (years)

0.106 (0.017) ***

0.056 (0.013) ***

 Anti-CCP2

0.003 (0.002)

0.001 (0.002)

 RF

0.000 (0.001)

0.000 (0.001)

 Anti-Sa positive

3.104 (0.747) ***

2.878 (0.543) ***

 CRP

0.032 (0.008) ***

0.025 (0.006) ***

GEE

ΔSvH ≥5 RR (95 % CI)

ΔErosion ≥5 RR (95 % CI)

 14-3-3η ≥0.50 ng/ml

2.176 (1.193–3.970) *

2.276 (1.448–3.577) ***

 Age ≥65 years

2.680 (1.859–3.864) ***

2.751 (1.760–4.301) ***

 Anti-CCP2-positive

1.048 (0.696–1.577)

1.134 (0.635–2.025)

 RF-positive

1.191 (0.739–1.921)

1.689 (1.042–2.738) *

 Anti-Sa-positive

1.537 (0.708–3.335)

2.507 (1.348–4.659) **

 CRP >8.0 mg/L

1.425 (1.112–1.826) **

1.834 (1.304–2.578) ***

 14-3-3η ≥0.50 * age ≥65 years

0.677 (0.396–1.156)

Not included

 14-3-3η ≥0.50 * RF-positive

0.724 (0.386–1.358)

0.552 (0.310–0.983) *

 14-3-3η ≥0.50 * anti-Sa positive

0.898 (0.470–1.717)

0.400 (0.204–0.786) **

 Age ≥65 * anti-CCP2 positive

0.899 (0.507–1.596)

0.692 (0.351–1.365)

 Age ≥65 * anti-Sa positive

0.593 (0.345–1.017)

Not included

 RF-positive * anti-Sa positive

1.256 (0.607–2.597)

Not included

 Anti-CCP2-positive * anti-Sa positive

Not included

0.856 (0.424–1.728)