Table 3 Heritability and biometric modelling in males with knee OA
Model in males | MZ prevalence | DZ prevalence | MZ rho | DZ rho | MZ cwc | DZ cwc | H | Variance component estimates | Chi-square test statistics | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | D | C | E | LL | –2ln | df | p value | AIC | ||||||||
Sat | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.66 (0.03–0.92) | 0.71 (0.39–0.87) | 0.26 (0.05–0.70) | 0.30 (0.13–0.55) | 0 (0.00–0.89) | – | – | – | – | –3387.1 | 0.021 | 1 | Compare CE, p = 0.65 | 6780.14 |
ACE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.7 (0.42–0.85) | 0.7 (0.42–0.85) | 0.29 (0.14–0.51) | 0.29 (0.14–0.51) | 0 | 0 | – | 0.69 (0.48–0.90) | 0.31 (0.1–0.52) | –3387.2 | 25.8 | 1 | Compared AE, p <0.0001 | 6780.35 |
ADE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.79 (0.45–0.93) | 0.39 (0.28–0.50) | 0.39 (0.18–0.66) | 0.10 (0.07–0.16) | 0.79 (0.57–1.0) | 0.79 (0.57–1.0) | 0 | – | 0.21 (0.0–0.43) | –3400.1 | 0 | 1 | Compare DE, p = 1.0 | 6806.14 |
AE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.79 (0.45–0.93) | 0.39 (0.28–0.50) | 0.39 (0.18–0.66) | 0.10 (0.07–0.16) | 0.79 (0.57–1.0) | 0.79 (0.57–1.0) | – | – | 0.21 (0.0–0.43) | –3400.1 | 25.8 | 1 | Compare Sat, p <0.0001 | 6804.14 |
CE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.69 (0.42–0.85) | 0.69 (0.42–0.85) | 0.29 (0.14–0.51) | 0.29 (0.14–0.51) | – | – | _ | 0.69 (0.48–0.90) | 0.31 (0.1–0.52) | –3387.2 | 0 | 1 | Compare ACE, p = 1.0 | 6778.35 |
DE | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.76 (0.38–0.92) | 0.19 (0.13–0.25) | 0.36 (0.14–0.66) | 0.04 (0.03–0.06) | 0.76 (0.51–1.0) | – | 0.76 (0.51–1.0) | – | 0.24 (0.00–0.49) | –3414.6 | 29.1 | 1 | Compare ADE, P <0.0001 | 6833.24 |