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Table 4 Heritability and biometric modelling in females with knee OA

From: Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty: a nationwide population based follow up study in Danish twins

Model in females

MZ prevalence

DZ prevalence

MZ rho

DZ rho

MZ cwc

DZ cwc

H

Variance component estimates

Chi-square test statistics

 

A

D

C

E

LL

–2ln

df

p value

AIC

Sat

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.77 (0.53–0.90)

0.74 (0.48–0.88)

0.42 (0.25–0.62)

0.39 (0.22–0.60)

0.06 (0.0–0.58)

–

–

–

–

–5877.6

34.2

1

Compare AE, p <0.0001

11,552.2

ACE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.77 (0.53–0.90)

0.74 (0.48–0.88)

0.42 (0.25–0.62)

0.39 (0.22–0.60)

0.06 (0.0–0.58)

0.06 (0.0–0.58)

–

0.71 (0.29–1.00)

0.23 (0.06–0.41)

–5877.6

34.2

1

Compare AE, p <0.0001

11,552.2

ADE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.80 (0.62–0.91)

0.40 (0.33–0.47)

0.46 (0.30–0.63)

0.15 (0.12–0.19)

0.80 (0.67–0.94)

0.80 (0.67–0.94)

0

–

0.20 (0.06–0.33)

–5894.8

0

1

Compare AE, p = 1.0

11,575.6

AE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.80 (0.62–0.91)

0.40 (0.33–0.47)

0.46 (0.30–0.63)

0.15 (0.12–0.19)

0.80 (0.67–0.94)

0.80 (0.67–0.94)

–

–

0.20 (0.06–0.33)

–5894.8

23.3

1

Compare Sat, p <0.0001

11,573.6

CE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.76 (0.60–0.86)

0.76 (0.60–0.86)

0.41 (0.28–0.55)

0.41 (0.28–0.55)

–

–

_

0.76 (0.63–0.88)

0.24 (0.12–0.37)

–5877.7

0.26

1

Compare ACE, p = 0.61

11,553.5

DE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.79 (0.59–0.90)

0.20 (0.16–0.24)

0.45 (0.38–0.63)

0.08 (0.06–0.09)

0.79 (0.64–0.94)

–

0.79 (0.64–0.94)

–

0.19 (0.05–0.33)

–5912.5

35.5

1

Compare ADE, p <0.0001

11,606.5

  1. A additive genetic, AIC Akaike’s Information Criterion, C common environment, cwc case-wise concordance rate, D dominant genetic, df degrees of freedom, DZ dizygotic, E unique environment, H broad sense heritability, LL = log likelihood of model, –2ln = Likelihood Ratio chi-square test, MZ monozygotic, rho tetrachoric correlation coefficient, Sat saturated model, OA osteoarthritis
  2. The ACE model in bold displayes the best model fit by the AIC. Fixing the common environmental component C at zero produced a significantly worse fit (p <0.0001)
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Arthritis Research & Therapy

ISSN: 1478-6362

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