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Table 5 Biometric models and chi-square test statistics, sex adjusted

From: Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty: a nationwide population based follow up study in Danish twins

Model

MZ prevalence

DZ prevalence

MZ rho

DZ rho

MZ cwc

DZ cwc

H

Variance component estimates

Chi-square test statistics

 

A

D

C

E

LL

–2ln

df

p value

AIC

Sat

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.79 (0.59–0.90)

0.70 (0.50–0.83)

0.44 (0.28–0.62)

0.35 (0.22–0.51)

0.18 (0.00–0.62)

–

–

–

–

–10014.6

3.87

1

Compare CE, p = 0.05

20,037.10

ACE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.79 (0.59–0.90)

0.70 (0.50–0.83)

0.44 (0.28–0.62)

0.35 (0.22–0.51)

0.18 (0.0–0.62)

0.18 (0.0–0.62)

–

0.61 (0.25–0.97)

0.21 (0.06–0.36)

–10014.5

44.6

1

Compare AE, p <0.0001

20,037.10

ADE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.83 (0.68–0.91)

0.41 (0.36–0.47)

0.49 (0.35–0.64)

0.16 (0.13–0.19)

0.83 (0.72–0.94)

0.83 (0.72–0.94)

0

–

0.17 (0.06–0.28)

–10036.8

0

1

Compare AE, p = 1.0

20,081.66

AE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.83 (0.68–0.91)

0.41 (0.36–0.47)

0.49 (0.35–0.64)

0.16 (0.13–0.19)

0.83 (0.72–0.94)

0.83 (0.72–0.94)

–

–

0.17 (0.06–0.28)

–10036.8

34.3

1

Compared ACE, p <0.0001

20,079.66

CE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.74 (0.61–0.83)

0.74 (0.61–0.83)

0.39 (0.29–0.51)

0.39 (0.29–0.51)

–

–

–

0.74 (0.63–0.85)

0.26 (0.15–0.37)

–10016.5

3.87

1

Compare ACE, p = 0.05

20,038.97

DE

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.82 (0.66–0.91)

0.20 (0.17–0.23)

0.48 (0.33–0.63)

0.08 (0.07–0.09)

0.81 (0.70–0.94)

–

0.82 (0.70–0.94)

–

0.18 (0.06–0.30)

–10067.7

61.7

1

Compare ADE, p <0.0001

20,141.35

  1. A additive genetic, AIC Akaike’s Information Criterion, C common environment, cwc case-wise concordance rate, D dominant genetic, df degrees of freedom, DZ dizygotic, E unique environment, H broad sense heritability, LL = log likelihood of model, –2ln = Likelihood Ratio chi-square test, MZ monozygotic, rho tetrachoric correlation coefficient, Sat saturated model.
  2. The ACE model in bold displayes the best model fit by the AIC. Fixing the common environmental component C at zero produced a significantly worse fit (p <0.0001).
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Arthritis Research & Therapy

ISSN: 1478-6362

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