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Table 1 Demographic data for the 321 pre-symptomatic, 187 patients with RA and 492 control subjects

From: Rheumatoid factor isotypes in relation to antibodies against citrullinated peptides and carbamylated proteins before the onset of rheumatoid arthritis

  Control subjects (n = 492) Pre-symptomatic individuals (n = 321) RA patients (n = 187)
Female sex, % 71.5 77.9 74.3
Median age, yr (IQR) 51.1 (20.1) 50.3 (20.0)a 57.1 (15.3)
Ever smoker, n/total (%) 221/462 (47.8) 197/308 (64.0)b 123/184 (66.8)b
HLA-shared epitopec, n (%) 224/481 (46.5) 198/304 (65.1)b 118/187 (63.1)b
  1. RA rheumatoid arthritis, IQR interquartile range, HLA human leucocyte antigen
  2. aMedian age, as calculated for all samples when collected (n = 598) at a median (IQR) of 62. (7.2) years before the onset of RA symptoms
  3. b p < 0.001 cases compared with controls
  4. cHLA-shared epitope = HLA-B1*0101/0401/0404/0405/0408