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Table 3 Diagnostic accuracy for SLE of the PNC assay, CLIFT, and their combined positivity in MRG patients

From: The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

  PNC+ CLIFT+ PNC+CLIFT+
Sensitivity (95 % CI) 0.20 (0.12–0.37) 0.32 (0.22–0.44) 0.15 (0.09–0.26)
Specificity (95 % CI) 0.95 (0.93–0.97) 0.95 (0.93–0.97) 0.99 (0.97–0.99)
PPV (95 % CI) 0.37 (0.23–0.54) 0.48 (0.34–0.62) 0.67 (0.42–0.85)
LR+ (95 % CI) 4.22 (2.24–7.96) 6.52 (3.83–11.10) 14.28 (5.04–40.46)
LR− (95 % CI) 0.84 (0.74–0.95) 0.71 (0.60–0.84) 0.86 (0.77–0.95)
  1. CI confidence interval, PPV positive predictive value, LR+ likelihood ratio for positive result, LR− likelihood ratio for negative result, CLIFT Crithidia luciliae immunofluorescence test, PNC phagocytosis of necrotic cell material, MRG multicenter rheumatic group, SLE systemic lupus erythematosus