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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Physiological evidence for diversification of IFNα- and IFNβ-mediated response programs in different autoimmune diseases

Fig. 2

Comparison of gene clusters in systemic lupus erythematosus (SLE) and interferon (IFN)β-treated multiple sclerosis (MS) patients. a Unsupervised cluster analysis of SLE patients with a type I interferon signature and IFNβ-treated MS patients. Patient groups were fully separated based on their expression profiles of 23 interferon response genes. Separation is based on differential expression of two major gene clusters. Significantly different genes comprising GC-A (blue) and GC-B (orange) are underlined. b GC-A and GC-B scores were compared in SLE and IFNβ-treated MS patients in the initial and additional cohort. In both cohorts, the GC-A score is higher than the GC-B score in SLE patients, whereas the opposite is true for IFNβ-treated MS patients. c The log-ratio of GC-A and GC-B scores was compared in SLE and IFNβ-treated MS patients from the initial and additional cohort. In all SLE patients, the ratio is above zero, indicating GC-A > GC-B. In virtually all IFNβ-treated MS patients, GC-A/GC-B ratio is below zero, indicating GC-B > GC-A. HC healthy controls

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