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Table 2 Annual changes in disease activity indices and serum MMP-3 levels

From: MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy

 

0 year

1 year

2 years

3 years

Number of patients

DAS28-ESR(4)

5.5 ± 1.2

4.1 ± 1.3***

3.8 ± 1.3***

3.6 ± 1.4***

129

DAS28-CRP(4)

4.8 ± 1.1

3.4 ± 1.2***

3.1 ± 1.2***

2.6 ± 1.3***

129

DAS28-ESR(3)

5.2 ± 1.1

4.2 ± 1.3***

4.0 ± 1.23***

3.9 ± 1.4***

161

DAS28-CRP(3)

4.5 ± 1.0

3.5 ± 1.2***

3.2 ± 1.2***

3.1 ± 1.3***

161

mHAQ

0.541 ± 0.470

0.269 ± 0.388***

0.205 ± 0.318***

0.180 ± 0.323***

129

MMP3, ng/ml

241.9 ± 304.2

178.5 ± 287.8**

174.7 ± 299.5***

181.5 ± 321.2***

157

  1. **p = 0.0015, ***p <0.0001 vs 0 year analyzed by the Wilcoxon signed-rank test. DAS28 disease activity score in 28 joints, ESR erythrocyte sedimentation rate, CRP C-reactive protein, mHAQ modified health assessment questionnaire, MMP matrix metalloproteinase-3