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Table 2 Baseline cytokine levels in ankylosing spondylitis patients and healthy controls

From: IL-23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients

  Ankylosing spondylitis (n = 86) Healthy controls (n = 47)
Cytokine Active-AS Control-AS p valuea   p valueb p valuec
  (BASDAI ≥4; n = 47) (BASDAI <4; n = 39)     
IL-17A (pg/ml) 1.62 (1.06–2.98) 1.57 (1.04–2.17) 0.45 1.57 (1.04–2.17) 0.48 0.90
IL-22 (ng/ml) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.68 0.00 (0.00–0.00) 0.47 0.78
IL-23 (ng/ml) 0.08 (0.04–0.17) 0.03 (0.01–0.08) <0.001 0.02 (0.00–0.05) <0.001 0.57
PGE2 (pg/ml) 19.46 (5.41–102.58) 7.67 (3.96–24.73) 0.008 7.66 (3.30–30.32) 0.02 0.99
  1. All values are expressed as the median (25–75 % interquartile range)
  2. aActive-AS vs. control-AS
  3. bActive-AS vs. healthy controls
  4. cControl-AS vs. healthy controls
  5. AS ankylosing spondylitis, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, IL interleukin, PGE2 prostaglandin E2