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Table 3 Micro-CT analysis and bone turnover

From: Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration

 

No BML (n = 12)

BML (1 + 2) (n = 44)

P value

Micro-CT - subchondral plate

 Pl.Th, mma

0.44 ± 0.10

0.95 ± 0.29

0.001

 Surface cl.poresb

49.5 (23, 83.7)

103.7 (60, 203)

0.007

Micro-CT - subchondral trabeculae

 BV/TV, %a

12.06 ± 3.5

16.7 ± 5.1

0.02

 Tb.N, number/mma

0.9 ± 0.2

1.2 ± 0.3

0.04

 Tb.Sp, mmb

0.9 (0.9, 1)

1.2 (1, 1.5)

0.06

 Tb.Th, mmb

0.13 (0.11, 0.15)

0.14 (0.12, 0.16)

0.2

 Tb.Pfa

-2.2 ± 3.7

-9.3 ± 7.8

0.02

 SMIa

1.32 ± 0.4

0.62 ± 0.8

0.02

 DAb

1.5 (1.4, 1.6)

1.6 (1.5, 1.8)

0.5

Bone remodeling - subchondral plate

 O.Th, μma

36 ± 8.9

43 ± 10.9

0.03

 OS/BS, %b

2.5 (1.1, 3.6)

5.1 (3.6, 7.2)

0.0001

 OS/BV, mm2/mm3b

1.9 (0.8, 2.8)

2 (1.5, 3.6)

0.3

 OS/TV, mm2/mm3a

0.4 ± 0.2

0.8 ± 0.4

0.004

 OV/BV, %b

7.1 (3.4, 8.8)

9.4 (6.1, 15)

0.08

 OV/TV, %b

1.6 (0.7, 2.1)

3.5 (2, 5.6

0.001

 ES/BS, %b

0.03 (0, 0.1)

0.09 (0.01, 0.17)

0.1

 ES/BV, mm2/mm3b

0.02 (0, 0.06)

0.03 (0.007, 0.07)

0.5

 ES/TV, mm2/mm3b

0.004 (0, 0.01)

0.01 (0.002, 0.02)

0.1

Bone remodeling - subchondral trabeculae

 O.Th, μmb

24.7 (22.4, 32.2)

38.1 (27.6, 46.3)

0.005

 OS/BS (%)b

3.4 (1.9, 3.9)

3 (1.4, 5.8)

0.6

 OS/BV, mm2/mm3b

1.9 (1.1, 2.9)

2.2 (1.4, 3.5)

0.3

 OS/TV, mm2/mm3b

0.4 (0.3, 0.5)

0.7 (0.4, 1.1)

0.04

 OV/BV, %b

3.6 (2.3, 5.5)

4.7 (2.0, 7.3)

0.04

 OV/TV, %b

1.2 (0.8, 1.7)

2 (1.2, 5.4)

0.008

 ES/BS, %b

0.2 (0.1, 0.5)

0.1 (0.09, 0.2)

0.02

 ES/BV, mm2/mm3b

0.1 (0.04, 0.1)

0.07 (0.05, 0.1)

0.8

 ES/TV, mm2/mm3b

0.02 (0.01, 0.03)

0.02 (0.01, 0.04)

0.7

  1. aValues presented with mean ± standard deviation. bValues presented with median (25th, 75th percentiles). P values are for difference between the group with no bone marrow lesions (no BML) and the group with BML (BML 1 + BML 2). cl.pores closed pores, Micro-CT micro computed tomography, BV bone volume, TV tissue volume, Tb.N trabecular number, Tb.Sp trabecular separation, SMI structural model index, Tb.Th trabecular thickness, O.Th osteoid thickness, OS osteoid surface, BS bone surface, ES erosion surface, OV osteoid volume, Pl.Th Plate thickness, Tb.Pf trabecular patern factor, DA degree of anisotropy