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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Anti-TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling

Fig. 3

Roles of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and Pi3 kinase in the induction of heme oxygenase 1 (HO-1) by certolizumab pegol (CZP). Monocytes were incubated, or not, with CZP 5 μg/ml in the presence or not of diphenyleneiodonium chloride (DPI) (10 μM) and wortmannin (0.4 μM) over 16 h. HO-1 was assessed by western blot. One representative blot is shown (a). Quantification of three western blot experiments was performed. *Paired t test <0.05 (b). GAPDH glyceraldehyde 3-phosphate dehydrogenase, WM Wortmannin

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