Fig. 3
From: Nicotinic acetylcholine receptors modulate osteoclastogenesis
Nicotine inhibits in vivo osteoclastogenesis. Calvarial bone resorption induced by subcutaneous injection of lipopolysaccharide (LPS) above the calvaria; LPS, phosphate-buffered saline (PBS), nicotine, or nicotine and LPS. Images in the bottom panel are representative of the indicated groups; scale bars = 100 μm. a Area of erosion/total tissue area; b number of osteoclasts