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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

Fig. 6

Ferulic acid (FLA) reduces joint tissue damage in tumor necrosis factor–transgenic (TNF-Tg) mice. Three-month-old TNF-Tg and wild-type (WT) mice were treated with FLA or saline, as described in Fig. 5. a Representative Alcian Blue/Orange G (ABOG)- and tartrate-resistant acid phosphatase (TRAP)-stained sections show decreased joint tissue damage, including decreased cartilage (blue arrow) and bone erosion (black arrow) and TRAP+ osteoclasts in an FLA-treated mouse which has relatively normal joint morphology. Quantitation of inflammatory area (b), bone area (c), cartilage area (d), and TRAP+ area (e). Values are the mean ± standard deviation of six to eight legs per group. *p < 0.05 vs. WT mice; # p < 0.05 vs. saline-treated TNF-Tg mice

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Arthritis Research & Therapy

ISSN: 1478-6362

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