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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Cartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo

Fig. 6

Osteoarthritis features in ephrin-B2 (EFNB2)Col2knockout (KO) cartilage conditional mice at 1 year old. Representative radiographs (a, b) and histological sections (c, d) of the knee joint of EFNB2fl/fl (n = 8) and EFNB2Col2KO cartilage conditional (n = 8) mice stained with Safranin O/fast green. Histograms show Osteoarthritis Research Society International (OARSI) scoring of the medial tibia (e) and medial condyle (f). g, h Histological sections of the hip joint stained with Safranin O/fast green. i Hip scoring according to the modified Mankin system. *Decrease in the joint space (b). Scale bar at 100 μm (d). Arrows indicate cartilage degradation (d, h). Histological sections at original magnification × 100. Data are expressed as the mean ± standard error of the mean and P values were determined by Mann–Whitney U test

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