TY - JOUR AU - Jay, G. D. PY - 1992 DA - 1992// TI - Characterization of a bovine synovial fluid lubricating factor. I. Chemical, surface activity and lubricating properties JO - Connect Tissue Res VL - 28 UR - https://doi.org/10.3109/03008209209014228 DO - 10.3109/03008209209014228 ID - Jay1992 ER - TY - JOUR AU - Jay, G. D. AU - Britt, D. E. AU - Cha, C. J. PY - 2000 DA - 2000// TI - Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts JO - J Rheumatol VL - 27 ID - Jay2000 ER - TY - STD TI - Flannery CR, Hughes CE, Schumacher BL, Tudor D, Aydelotte MB, Kuettner KE, Caterson B. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. Biochem Biophys Res Commun. 1999;254(3):535–41. ID - ref3 ER - TY - STD TI - Jay GD, Torres JR, Rhee DK, Helminen HJ, Hytinnen MM, Cha CJ, Elsaid K, Kim KS, Cui Y, Warman ML. Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum. 2007;56(11):3662–9. ID - ref4 ER - TY - JOUR AU - Gleghorn, J. P. AU - Jones, A. R. AU - Flannery, C. R. AU - Bonassar, L. J. PY - 2009 DA - 2009// TI - Boundary mode lubrication of articular cartilage by recombinant human lubricin JO - J Orthop Res VL - 27 UR - https://doi.org/10.1002/jor.20798 DO - 10.1002/jor.20798 ID - Gleghorn2009 ER - TY - STD TI - Rhee DK, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, Jay GD, Stewart M, Wang H, Warman ML et al. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005;115(3):622–31. ID - ref6 ER - TY - JOUR AU - Wong, B. L. AU - Bae, W. C. AU - Chun, J. AU - Gratz, K. R. AU - Lotz, M. AU - Sah, R. L. PY - 2008 DA - 2008// TI - Biomechanics of cartilage articulation: effects of lubrication and degeneration on shear deformation JO - Arthritis Rheum VL - 58 UR - https://doi.org/10.1002/art.23548 DO - 10.1002/art.23548 ID - Wong2008 ER - TY - JOUR AU - Waller, K. A. AU - Zhang, L. X. AU - Elsaid, K. A. AU - Fleming, B. C. AU - Warman, M. L. AU - Jay, G. D. PY - 2013 DA - 2013// TI - Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1219289110 DO - 10.1073/pnas.1219289110 ID - Waller2013 ER - TY - JOUR AU - Elsaid, K. A. AU - Jay, G. D. AU - Warman, M. L. AU - Rhee, D. K. AU - Chichester, C. O. PY - 2005 DA - 2005// TI - Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis JO - Arthritis Rheum VL - 52 UR - https://doi.org/10.1002/art.21038 DO - 10.1002/art.21038 ID - Elsaid2005 ER - TY - JOUR AU - Elsaid, K. A. AU - Jay, G. D. AU - Chichester, C. O. PY - 2007 DA - 2007// TI - Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis JO - Arthritis Rheum VL - 56 UR - https://doi.org/10.1002/art.22321 DO - 10.1002/art.22321 ID - Elsaid2007 ER - TY - JOUR AU - Elsaid, K. A. AU - Machan, J. T. AU - Waller, K. AU - Fleming, B. C. AU - Jay, G. D. PY - 2009 DA - 2009// TI - The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24800 DO - 10.1002/art.24800 ID - Elsaid2009 ER - TY - STD TI - Jones AR, Chen S, Chai DH, Stevens AL, Gleghorn JP, Bonassar LJ, Grodzinsky AJ, Flannery CR. Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum. 2009;60(1):133–42. ID - ref12 ER - TY - STD TI - Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy RM, Jay GD. Decreased lubricin concentrations and markers of joint inflammation in synovial fluids from patients with anterior cruciate ligament injury. Arthritis Rheum. 2008;58(6):1707–15. ID - ref13 ER - TY - JOUR AU - Musumeci, G. AU - Loreto, C. AU - Carnazza, M. L. AU - Martinez, G. PY - 2011 DA - 2011// TI - Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis JO - Knee Surg Sports Traumatol Arthrosc VL - 19 UR - https://doi.org/10.1007/s00167-010-1215-0 DO - 10.1007/s00167-010-1215-0 ID - Musumeci2011 ER - TY - JOUR AU - Thomas, C. M. AU - Fuller, C. J. AU - Whittles, C. E. AU - Sharif, M. PY - 2011 DA - 2011// TI - Chondrocyte death by apoptosis is associated with the initiation and severity of articular cartilage degradation JO - Int J Rheum Dis VL - 14 UR - https://doi.org/10.1111/j.1756-185X.2010.01578.x DO - 10.1111/j.1756-185X.2010.01578.x ID - Thomas2011 ER - TY - JOUR AU - Almonte-Becerril, M. AU - Navarro-Garcia, F. AU - Gonzalez-Robles, A. AU - Vega-Lopez, M. A. AU - Lavalle, C. AU - Kouri, J. B. PY - 2010 DA - 2010// TI - Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model JO - Apoptosis VL - 15 UR - https://doi.org/10.1007/s10495-010-0458-z DO - 10.1007/s10495-010-0458-z ID - Almonte-Becerril2010 ER - TY - JOUR AU - Aigner, T. AU - McKenna, L. PY - 2002 DA - 2002// TI - Molecular pathology and pathobiology of osteoarthritic cartilage JO - Cell Mol Life Sci VL - 59 UR - https://doi.org/10.1007/s00018-002-8400-3 DO - 10.1007/s00018-002-8400-3 ID - Aigner2002 ER - TY - JOUR AU - Drewniak, E. I. AU - Jay, G. D. AU - Fleming, B. C. AU - Zhang, L. AU - Warman, M. L. AU - Crisco, J. J. PY - 2012 DA - 2012// TI - Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees JO - Arthritis Rheum VL - 64 UR - https://doi.org/10.1002/art.33337 DO - 10.1002/art.33337 ID - Drewniak2012 ER - TY - STD TI - Hill A, Waller KA, Cui Y, Allen JM, Smits P, Zhang LX, Ayturk UM, Hann S, Lessard SG, Zurakowski D et al. Lubricin restoration in a mouse model of congenital deficiency. Arthritis Rheumatol. 2015;67(11):3070–81. ID - ref19 ER - TY - JOUR AU - Elsaid, K. A. AU - Zhang, L. AU - Shaman, Z. AU - Patel, C. AU - Schmidt, T. A. AU - Jay, G. D. PY - 2015 DA - 2015// TI - The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model JO - Osteoarthritis Cartilage VL - 23 UR - https://doi.org/10.1016/j.joca.2014.09.006 DO - 10.1016/j.joca.2014.09.006 ID - Elsaid2015 ER - TY - JOUR AU - Grogan, S. P. AU - Aklin, B. AU - Frenz, M. AU - Brunner, T. AU - Schaffner, T. AU - Mainil-Varlet, P. PY - 2002 DA - 2002// TI - In vitro model for the study of necrosis and apoptosis in native cartilage JO - J Pathol VL - 198 UR - https://doi.org/10.1002/path.1169 DO - 10.1002/path.1169 ID - Grogan2002 ER - TY - JOUR AU - Dang, A. C. AU - Kim, H. T. PY - 2009 DA - 2009// TI - Chondrocyte apoptosis after stimulated intraarticular fracture: a comparison of histologic detection methods JO - Clin Orthop Relat Res VL - 467 UR - https://doi.org/10.1007/s11999-009-0829-3 DO - 10.1007/s11999-009-0829-3 ID - Dang2009 ER - TY - STD TI - Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 1988;96(5):379–94. ID - ref23 ER - TY - JOUR AU - Mandarim-de-Lacerda, C. A. PY - 2003 DA - 2003// TI - Stereological tools in biomedical research JO - An Acad Bras Cienc VL - 75 UR - https://doi.org/10.1590/S0001-37652003000400006 DO - 10.1590/S0001-37652003000400006 ID - Mandarim-de-Lacerda2003 ER - TY - JOUR AU - Guilak, F. PY - 1994 DA - 1994// TI - Volume and surface area measurement of viable chondrocytes in situ using geometric modelling of serial confocal sections JO - J Microsc VL - 173 UR - https://doi.org/10.1111/j.1365-2818.1994.tb03447.x DO - 10.1111/j.1365-2818.1994.tb03447.x ID - Guilak1994 ER - TY - STD TI - Ruan MZ, Erez A, Guse K, Dawson B, Bertin T, Chen Y, Jiang MM, Yustein J, Gannon F, Lee BH. Proteoglycan 4 expression protects against the development of osteoarthritis. Sci Transl Med. 2013;5(176):176ra134. ID - ref26 ER - TY - JOUR AU - Mouton, P. R. AU - Gokhale, A. M. AU - Ward, N. L. AU - West, M. J. PY - 2002 DA - 2002// TI - Stereological length estimation using spherical probes JO - J Microsc VL - 206 UR - https://doi.org/10.1046/j.1365-2818.2002.01006.x DO - 10.1046/j.1365-2818.2002.01006.x ID - Mouton2002 ER - TY - STD TI - Aherne WA, Dunhill MS. Morphometry. London: Edward Arnold; 1982. ID - ref28 ER - TY - STD TI - Howard CV, Reed MG. Unbiased Stereology. 2nd ed. New York: Garland Science/BIOS Scientific Publishers; 2005. ID - ref29 ER - TY - JOUR AU - Kotwal, N. AU - Li, J. AU - Sandy, J. AU - Plaas, A. AU - Sumner, D. R. PY - 2012 DA - 2012// TI - Initial application of EPIC-muCT to assess mouse articular cartilage morphology and composition: effects of aging and treadmill running JO - Osteoarthritis Cartilage VL - 20 UR - https://doi.org/10.1016/j.joca.2012.04.012 DO - 10.1016/j.joca.2012.04.012 ID - Kotwal2012 ER - TY - JOUR AU - Brown, T. D. AU - Johnston, R. C. AU - Saltzman, C. L. AU - Marsh, J. L. AU - Buckwalter, J. A. PY - 2006 DA - 2006// TI - Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease JO - J Orthop Trauma VL - 20 UR - https://doi.org/10.1097/01.bot.0000246468.80635.ef DO - 10.1097/01.bot.0000246468.80635.ef ID - Brown2006 ER - TY - STD TI - Anderson DD, Chubinskaya S, Guilak F, Martin JA, Oegema TR, Olson SA, Buckwalter JA. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res. 2011;29(6):802–9. ID - ref32 ER - TY - STD TI - Coles JM, Zhang L, Blum JJ, Warman ML, Jay GD, Guilak F, Zauscher S. Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum. 2010;62(6):1666–74. ID - ref33 ER - TY - STD TI - Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B et al. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Nat Genet. 1999;23(3):319–22. ID - ref34 ER - TY - JOUR AU - Wong, M. AU - Wuethrich, P. AU - Eggli, P. AU - Hunziker, E. PY - 1996 DA - 1996// TI - Zone-specific cell biosynthetic activity in mature bovine articular cartilage: a new method using confocal microscopic stereology and quantitative autoradiography JO - J Orthop Res VL - 14 UR - https://doi.org/10.1002/jor.1100140313 DO - 10.1002/jor.1100140313 ID - Wong1996 ER - TY - STD TI - Moyer CE, Delevich KM, Fish KN, Asafu-Adjei JK, Sampson AR, Dorph-Petersen KA, Lewis DA, Sweet RA. Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia. Schizophr Res. 2013;149(1-3):127–34. ID - ref36 ER - TY - JOUR AU - Hunziker, E. B. AU - Quinn, T. M. AU - Hauselmann, H. J. PY - 2002 DA - 2002// TI - Quantitative structural organization of normal adult human articular cartilage JO - Osteoarthritis Cartilage VL - 10 UR - https://doi.org/10.1053/joca.2002.0814 DO - 10.1053/joca.2002.0814 ID - Hunziker2002 ER - TY - STD TI - Stockwell RA. Chondrocytes. J Clin Pathol Suppl (R Coll Pathol). 1978;12:7–13. ID - ref38 ER - TY - STD TI - Rhee DK, Marcelino J, Al-Mayouf S, Schelling DK, Bartels CF, Cui Y, Laxer R, Goldbach-Mansky R, Warman ML. Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing. J Biol Chem. 2005;280(35):31325–32. ID - ref39 ER - TY - STD TI - Teeple E, Aslani K, Shalvoy MR, Medrano JE, Zhang L, Machan JT, Fleming BC, Jay GD. Lubricin deficiency in the murine lumbar intervertebral disc results in elevated torsional apparent modulus. J Biomech. 2015;48(10):2210–3. ID - ref40 ER - TY - STD TI - Jones MH, Spindler KP, Fleming BC, Duryea J, Obuchowski NA, Scaramuzza EA, Oksendahl HL, Winalski CS, Duong CL, Huston LJ et al. Meniscus treatment and age associated with narrower radiographic joint space width 2-3 years after ACL reconstruction: data from the MOON onsite cohort. Osteoarthritis Cartilage. 2015;23(4):581–8. ID - ref41 ER - TY - JOUR AU - Wei, L. AU - Bri, E. AU - Lundberg, A. AU - Svensson, O. PY - 1998 DA - 1998// TI - Mechanical load and primary guinea pig osteoarthrosis JO - Acta Orthop Scand VL - 69 UR - https://doi.org/10.3109/17453679808999046 DO - 10.3109/17453679808999046 ID - Wei1998 ER - TY - JOUR AU - Wang, S. X. AU - Arsenault, L. AU - Hunziker, E. B. PY - 2011 DA - 2011// TI - Stereologic analysis of tibial-plateau cartilage and femoral cancellous bone in guinea pigs with spontaneous osteoarthritis JO - Clin Orthop Relat Res VL - 469 UR - https://doi.org/10.1007/s11999-011-1899-6 DO - 10.1007/s11999-011-1899-6 ID - Wang2011 ER - TY - STD TI - Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. Structural basis for the inhibition of caspase-3 by XIAP. Cell. 2001;104(5):791–800. ID - ref44 ER - TY - JOUR AU - Jones, K. H. AU - Senft, J. A. PY - 1985 DA - 1985// TI - An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide JO - J Histochem Cytochem VL - 33 UR - https://doi.org/10.1177/33.1.2578146 DO - 10.1177/33.1.2578146 ID - Jones1985 ER - TY - JOUR AU - Rotman, B. AU - Papermaster, B. W. PY - 1966 DA - 1966// TI - Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters JO - Proc Natl Acad Sci U S A VL - 55 UR - https://doi.org/10.1073/pnas.55.1.134 DO - 10.1073/pnas.55.1.134 ID - Rotman1966 ER - TY - JOUR AU - Boyd, V. AU - Cholewa, O. M. AU - Papas, K. K. PY - 2008 DA - 2008// TI - Limitations in the use of fluorescein diacetate/propidium iodide (FDA/PI) and cell permeable nucleic acid stains for viability measurements of isolated islets of Langerhans JO - Curr Trends Biotechnol Pharm VL - 2 ID - Boyd2008 ER - TY - JOUR AU - Hughes, L. C. AU - Archer, C. W. AU - ap Gwynn, I. PY - 2005 DA - 2005// TI - The ultrastructure of mouse articular cartilage: collagen orientation and implications for tissue functionality. A polarised light and scanning electron microscope study and review JO - Eur Cell Mater VL - 9 UR - https://doi.org/10.22203/eCM.v009a09 DO - 10.22203/eCM.v009a09 ID - Hughes2005 ER - TY - STD TI - Young AA, McLennan S, Smith MM, Smith SM, Cake MA, Read RA, Melrose J, Sonnabend DH, Flannery CR, Little CB. Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Res Ther. 2006;8(2):R41. ID - ref49 ER - TY - JOUR AU - Waller, K. A. AU - Zhang, L. X. AU - Fleming, B. C. AU - Jay, G. D. PY - 2012 DA - 2012// TI - Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid and hylan G-F 20 JO - J Rheumatol VL - 39 UR - https://doi.org/10.3899/jrheum.111427 DO - 10.3899/jrheum.111427 ID - Waller2012 ER - TY - STD TI - Hashimoto S, Nishiyama T, Hayashi S, Fujishiro T, Takebe K, Kanzaki N, Kuroda R, Kurosaka M. Role of p53 in human chondrocyte apoptosis in response to shear strain. Arthritis Rheum. 2009;60(8):2340–9. ID - ref51 ER - TY - JOUR AU - D’Lima, D. D. AU - Hashimoto, S. AU - Chen, P. C. AU - Colwell, C. W. AU - Lotz, M. K. PY - 2001 DA - 2001// TI - Impact of mechanical trauma on matrix and cells JO - Clin Orthop Rel Res VL - 391S UR - https://doi.org/10.1097/00003086-200110001-00009 DO - 10.1097/00003086-200110001-00009 ID - D’Lima2001 ER - TY - JOUR AU - Ludwig, T. E. AU - McAllister, J. R. AU - Lun, V. AU - Wiley, J. P. AU - Schmidt, T. A. PY - 2012 DA - 2012// TI - Diminished cartilage-lubricating ability of human osteoarthritic synovial fluid deficient in proteoglycan 4: Restoration through proteoglycan 4 supplementation JO - Arthritis Rheum VL - 64 UR - https://doi.org/10.1002/art.34674 DO - 10.1002/art.34674 ID - Ludwig2012 ER - TY - STD TI - Jay GD, Fleming BC, Watkins BA, McHugh KA, Anderson SC, Zhang LX, Teeple E, Waller KA, Elsaid KA. Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum. 2010;62(8):2382–91. ID - ref54 ER - TY - STD TI - Teeple E, Elsaid KA, Jay GD, Zhang L, Badger GJ, Akelman M, liss TF, Fleming BC. Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee. Am J Sports Med. 2011;39(1):164–72. ID - ref55 ER - TY - STD TI - Jay GD, Elsaid KA, Kelly KA, Anderson SC, Zhang L, Teeple E, Waller K, Fleming BC. Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum. 2012;64(4):1162–71. ID - ref56 ER - TY - STD TI - Elsaid KA, Zhang L, Waller K, Tofte J, Teeple E, Fleming BC, Jay GD. The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin’s effect in exercised joints following ACL transection. Osteoarthritis Cartilage. 2012;20(8):940–8. ID - ref57 ER - TY - STD TI - Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermudez MA, Blanchet T, Gleghorn JP, Bonassar LJ, Bendele AM et al. Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum. 2009;60(3):840–7. ID - ref58 ER - TY - STD TI - Teeple E, Elsaid KA, Fleming BC, Jay GD, Aslani K, Crisco JJ, Mechrefe AP. Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig knee. J Orthop Res. 2008;26(2):231–7. ID - ref59 ER -