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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis

Fig. 4

a Coronal sections of ten-week-old Prg4 mutant mouse medial and lateral femoral condyles stained positive for activated capsase-3. Cells positive for activated caspase-3 are stained pink, while negative nuclei are blue. b No significant differences were observed in the total number of chondrocytes in superficial and upper intermediate zones (14 μm depth from the edge of the condyle) for Prg4 +/+, Prg4 +/- and Prg4 -/- littermates. c Prg4 -/- femoral condyle cartilage had a significantly higher number of cells positive for activated caspase-3 in the superficial and upper intermediate zones (14 μm depth from the edge of the condyle) in the medial femoral condyle compared to Prg4 +/- (p = 0.04) and Prg4 +/+(p = 0.01) cartilage. There was a significantly higher number of caspase positive cells in lateral femoral condyle in Prg4 -/- mice compared to Prg4 +/- (p = 0.02) and Prg4 +/+(p = 0.01) littermates. Scale bars indicate 20 μm

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