Table 1 Characteristics of patients with a clinical diagnosis of axial spondyloarthritis starting a second tumor necrosis factor inhibitor
Parameter | Number of patients | PLR (n = 146) | SLR (n = 270) | AE (n = 125) | Other (n = 91) | p Value |
|---|---|---|---|---|---|---|
Male sex, % | 632 | 47.3 | 56.3 | 46.4 | 52.8 | 0.20 |
Age, years | 632 | 43.8 ± 10.5 | 44.4 ± 11.1 | 44.1 ± 12.3 | 45.0 ± 13.1 | 0.87 |
Radiographic axSpA, % | 454 | 54.4 | 69.2 | 65.8 | 82.1 | 0.003 |
HLA-B27–positive, % | 510 | 43.2 | 67.1 | 64.3 | 71.0 | <0.001 |
Elevated CRP, % | 361 | 30.4 | 34.2 | 42.7 | 29.2 | 0.33 |
ASDAS-CRP | 316 | 3.4 ± 0.8 | 3.1 ± 0.9 | 3.0 ± 1.1 | 2.7 ± 1.0 | <0.001 |
ASDAS-ESR | 289 | 3.1 ± 0.8 | 2.8 ± 0.8 | 2.8 ± 1.2 | 2.6 ± 1.2 | 0.03 |
BASDAI | 348 | 6.0 ± 1.8 | 5.2 ± 2.0 | 4.9 ± 2.3 | 4.5 ± 2.3 | <0.001 |
BASFI | 345 | 4.6 ± 2.5 | 4.1 ± 2.5 | 3.7 ± 2.5 | 2.8 ± 2.3 | 0.001 |
BASMI | 288 | 2.1 ± 1.9 | 2.3 ± 2.0 | 2.4 ± 2.1 | 2.7 ± 1.9 | 0.36 |
Peripheral arthritis, % | 629 | 41.4 | 37.0 | 31.7 | 30.8 | 0.26 |
Enthesitis heel, % | 632 | 42.5 | 31.9 | 26.4 | 24.2 | 0.01 |
Smokers, % | 602 | 67.6 | 57.2 | 69.0 | 50.0 | 0.01 |
DMARDs, % | 632 | 21.2 | 24.1 | 12.0 | 24.2 | 0.03 |
NSAIDs, % | 632 | 62.3 | 54.4 | 48.0 | 39.6 | 0.003 |
BMI, kg/m2 | 608 | 26.3 ± 4.9 | 25.6 ± 4.9 | 25.9 ± 4.7 | 25.7 ± 4.7 | 0.58 |
Years of education | 596 | 13.0 ± 3.0 | 13.5 ± 3.0 | 13.3 ± 2.9 | 14.1 ± 3.2 | 0.07 |