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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

Fig. 2

Effect of DK226 on proliferation of human synovial fibroblast-like cells (HFLS) and of human synovial sarcoma cell line SW982. a Inhibition of tumor necrosis alpha (TNF-α)-induced proliferation of HFLS by hyaluronic acid (HA) or DK226 at increasing, equivalent HA concentrations. b Effect of exogenously added HA on the anti-proliferative effect of DK226 in HFLS. c Inhibition of proliferation of SW982 by methotrexate (MTX) or DK226 at increasing, equivalent MTX concentrations. d Effect of exogenously added anti-CD44 antibody (BU75) and anti-IgG2a (control antibody) on the anti-proliferative effect of DK226 in SW982. Values are means and standard error of the mean (SEM) (n = 4)

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