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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis

Fig. 2

Expression of CD244 (CD28null) and FOXP3 among T-cell infiltrates in muscle tissue of myositis patients. Immunohistochemistry of muscle tissue obtained from the patients before the start of immunosuppressive treatment are shown with representative staining of CD3 (a), CD244 (b), isotype control for CD244 (c) and FOXP3 (d). Both CD244+ cells/mm2 (95 % CI = 0.75 to 0.97) (e) and FOXP3+ cells/mm2 (95 % CI = 0.66 to 0.96) (f) strongly correlated with CD3+ cells/mm2. The number of FOXP3+ cells was significantly lower than CD244+ cells in myositis muscle tissue (g). When compared to total CD3+ cells, CD244+ cells were present in approximately 10-fold higher proportion compared with FOXP3+ in the myositis muscle tissue (h). *p < 0.05, ***p < 0.001. CI confidence interval, r s Spearman correlation coefficient

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Arthritis Research & Therapy

ISSN: 1478-6362

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