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Table 2 Univariate and multivariable association of 14-3-3η, ACPA and RF with arthritis development

From: A prospective cohort study of 14-3-3η in ACPA and/or RF-positive patients with arthralgia

Univariate logistic regression
Variable RR (95 % CI) p value
14-3-3η   
 Cut-off ≥0.19 2.5 (1.2–5.6) 0.02
 Cut-off ≥0.40 1.7 (1.0–2.8) 0.04
 Cut-off ≥0.80 2.2 (1.3–3.5) <0.01
 Levels 1.04 (1.01–1.07) 0.01
Multivariable logistic regression
Variable RR (95 % CI) p value
Categorical variable:   
 RF Reference  
 ACPA 7.9 (1.9–32.4) <0.01
 RF and ACPA 15.0 (3.8–59.7) <0.01
Adding 14-3-3η to the above categorical variable
14-3-3η ≥0.19 1.6 (0.7–3.5)* 0.25
14-3-3η ≥0.40 1.2 (0.7–1.8) 0.52
14-3-3η ≥0.80 1.3 (0.8–2.1) 0.36
14-3-3η levels 1.01 (0.98–1.04)** 0.50
  1. Abbreviations: ACPA anti-citrullinated protein antibodies, RF rheumatoid factor, RR relative risk, CI confidence interval
  2. *Interpretation of the relative risk, example: subjects that are 14-3-3η positive at the 0.19 cut-off point have a 1.6 times higher risk of developing arthritis, given the knowledge that these subjects must be either RF or ACPA positive
  3. **For continuous variables the relative risk conveys the higher risk of developing arthritis per ascending unit of the independent variable, in this case 14-3-3η