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Table 1 General characteristics of the study participants

From: Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort

Baseline variables

Total cohort, n = 3011

Study subjects, n = 1335

  

All subjects at baseline

OA at baseline, n = 238

OA at follow-up, n = 326

No OA at follow-up, n = 955

Female, n (%)

1694 (56)

743 (55.7)

144 (60.5)

195 (59.8)

519 (54.4)

Age*

65.2 (8.43)

63.1 (6.48)

66.4 (7.90)

66.02 (7.72)

62.13 (5.71)

Body mass index, kg/m2*

27.3 (4.23)

27.04 (3.85)

27.96 (4.11)

28.01 (4.29)

26.69 (3.65)

Current alcohol drinker, n (%)

2455 (81.5)

1146 (85.8)

205 (86.1)

277 (85)

822 (86.2)

Current smoking, n (%)

692 (23)

298 (22.3)

37 (15.5)

59 (18.1)

226 (23.7)

Low level of education, n (%)

424 (31.8)

999 (33.9)

74 (31.1)

103 (31.6)

298 (31.2)

Diabetes, n (%)

182 (6.0)

68 (5.1)

12 (5.0)

21 (6.4)

42 (4.4)

Knee pain, n (%)

725 (24.1)

328 (24.6)

96 (40.3)

128 (39.3)

185 (19.4)

Hip pain, n (%)

458 (15.2)

207 (15.5)

48 (20.2)

62 (19)

132 (13.8)

Knee OA, n (%)

339 (11.3)

185 (13.9)

185 (78.1)

185 (56.7)

-

Hip OA, n (%)

141 (4.7)

68 (5.1)

68 (28.7)

68 (20.9)

-

uCTX-II*, ng/mmol

-

2.3 (0.23)

2.42 (0.27)

2.40 (0.26)

2.27 (0.22)

COMP*, U/L

-

1.03 (0.10)

1.06 (0.10)

1.06 (0.10)

1.02 (0.10)

CRP*, mg/l

-

0.02 (0.49)

0.07 (0.48)

0.12 (0.49)

-0.02 (0.48)

CRPM*, ng/ml

-

1.01 (0.18)

1.01 (0.18)

1.02 (0.18)

1.01 (0.17)

C1M*, ng/ml

-

1.59 (0.17)

1.60 (0.18)

1.61 (0.18)

1.58 (0.17)

  1. OA osteoarthritis, uCTX-II (urinary) type II collagen degradation, COMP cartilage oligomeric protein, CPR C-reactive protein, CRPM matrix metalloproteinase-dependent degradation of CRP, C1M connective tissue type I collagen turnover
  2. *Mean (SD); levels of biomarkers are log10-trasformed