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Table 1 General characteristics of the study participants

From: Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort

Baseline variables Total cohort, n = 3011 Study subjects, n = 1335
   All subjects at baseline OA at baseline, n = 238 OA at follow-up, n = 326 No OA at follow-up, n = 955
Female, n (%) 1694 (56) 743 (55.7) 144 (60.5) 195 (59.8) 519 (54.4)
Age* 65.2 (8.43) 63.1 (6.48) 66.4 (7.90) 66.02 (7.72) 62.13 (5.71)
Body mass index, kg/m2* 27.3 (4.23) 27.04 (3.85) 27.96 (4.11) 28.01 (4.29) 26.69 (3.65)
Current alcohol drinker, n (%) 2455 (81.5) 1146 (85.8) 205 (86.1) 277 (85) 822 (86.2)
Current smoking, n (%) 692 (23) 298 (22.3) 37 (15.5) 59 (18.1) 226 (23.7)
Low level of education, n (%) 424 (31.8) 999 (33.9) 74 (31.1) 103 (31.6) 298 (31.2)
Diabetes, n (%) 182 (6.0) 68 (5.1) 12 (5.0) 21 (6.4) 42 (4.4)
Knee pain, n (%) 725 (24.1) 328 (24.6) 96 (40.3) 128 (39.3) 185 (19.4)
Hip pain, n (%) 458 (15.2) 207 (15.5) 48 (20.2) 62 (19) 132 (13.8)
Knee OA, n (%) 339 (11.3) 185 (13.9) 185 (78.1) 185 (56.7) -
Hip OA, n (%) 141 (4.7) 68 (5.1) 68 (28.7) 68 (20.9) -
uCTX-II*, ng/mmol - 2.3 (0.23) 2.42 (0.27) 2.40 (0.26) 2.27 (0.22)
COMP*, U/L - 1.03 (0.10) 1.06 (0.10) 1.06 (0.10) 1.02 (0.10)
CRP*, mg/l - 0.02 (0.49) 0.07 (0.48) 0.12 (0.49) -0.02 (0.48)
CRPM*, ng/ml - 1.01 (0.18) 1.01 (0.18) 1.02 (0.18) 1.01 (0.17)
C1M*, ng/ml - 1.59 (0.17) 1.60 (0.18) 1.61 (0.18) 1.58 (0.17)
  1. OA osteoarthritis, uCTX-II (urinary) type II collagen degradation, COMP cartilage oligomeric protein, CPR C-reactive protein, CRPM matrix metalloproteinase-dependent degradation of CRP, C1M connective tissue type I collagen turnover
  2. *Mean (SD); levels of biomarkers are log10-trasformed