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Table 3 Adjusted odds ratios (OR) and 95 % confidence intervals (CI) from logistic regression models for incident and progression of osteoarthritis (OA) in relation to biomarkers levels

From: Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort

  Incidence of OA, n = 88/955 Progression of OA*, n = 170/1125
  OR (95 % CI) p value OR (95 % CI) p value
uCTX-II 1.3 (1.0–1.7) 0.05 1.3 (1.1–1.5) 0.01
COMP 1.3 (1.1–1.6) 0.02 1.2 (1.04–1.5) 0.02
CRPM 1.2 (1.0–1.5) 0.07 1.3 (1.1–1.5) 0.01
C1M 1.1 (0.9–1.4) 0.23 1.1 (1.0–1.4) 0.10
CRP 1.5 (1.2–1.9) 0.0003 1.3 (1.1–1.5) 0.01
Full model
uCTX-II 1.3 (1.0–1.7) 0.05 1.3 (1.1–1.5) 0.01
COMP 1.3 (1.0–1.6) 0.03 1.2 (1.02–1.5) 0.03
CRPM 1.2 (0.9–1.5) 0.17 1.2 (1.01–1.5) 0.04
C1M 0.8 (0.6–1.1) 0.11 1.0 (0.8–1.2) 0.67
CRP 1.8 (1.3–2.4) 0.0003 1.3 (1.02–1.6) 0.03
  1. OA incident defined as Kellgren and Lawrence (KL) ≥2 at knee and/or hip; models were adjusted for age, sex, and body mass index; full models include all biomarkers adjusted for age, sex, and body mass index
  2. uCTX-II (urinary) type II collagen degradation, COMP cartilage oligomeric protein, CRPM matrix metalloproteinase-dependent degradation of CRP, C1M tissue type I collagen turnover, CRP C-reactive protein
  3. Case number/control number; progressed/no-progressed; *additionally adjusted for prevalent OA