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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Regulatory and effector B cell cytokine production in patients with relapsing granulomatosis with polyangiitis

Fig. 3

Changes in B cell cytokine production before relapse. For 11 relapsing patients two consecutive time points before relapse were analyzed simultaneously, to determine whether changes in cytokine production occurred prior to relapse. Peripheral blood mononuclear cells were cultured without CpG-oligodeoxynucleotides (CpG-ODN) (a-d) and with CpG-ODN (e). Total percentages of cytokine-producing B cells were determined within the CD19+CD22+ B cell population. Graphs represent data from 11 patients and each connected line represents an individual patient. The different symbols indicate the individual patients in each subgraph. R-1 indicates the sample taken closest to relapse and R-2 the sample taken before. *P < 0.05

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