Skip to main content
Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Human embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase

Fig. 4

Embryonic stem cell-derived mesenchymal stromal cells (hESC-MSC) migrate to the inguinal lymph nodes (ILN) and induce expression of murine indoleamine 2,3 dioxygenase (IDO1). a Expression of HLA-C transcripts in the ILN of mice with collagen-induced arthritis (CIA) treated with hESC-MSC compared to the phosphate-buffered saline (PBS)-treated group. b Expression of murine IDO1 (mIDO1) in the ILN of mice with CIA treated with vehicle (PBS) or with hESC-MSC and showing evidence of migration (HLA+) or not (HLA). Data show values from individual mice and the mean of the experimental groups. Statistical differences were analyzed by Kruskall-Wallis analysis of variance and Dunn’s multiple comparisons test. *P < 0.05; **P < 0.01

Back to article page