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Table 4 Comparison of clinical and laboratory side effects of colchicine in subsequent visits

From: Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever – a randomized controlled noninferiority trial

  Once-daily dosage group (n = 42) Twice-daily dosage group (n = 37)
Baseline First visit Second visit Baseline First visit Second visit p Valuea
Anorexia, % 0 19 16.7 0 10.8 16.2 0.545
Nausea, % 0 2.4 2.4 0 5.4 5.4 0.392
Diarrhea, % 0 19 2.4 0 10.8 2.7 0.403
Abdominal pain, % 0 9.5 11.9 0 10.8 8.1 0.800
Vomiting, % 0 4.8 0 0 8.1 5.4 0.290
Elevated ALT, % 2.4 9.5 7.1 2.7 10.8 2.7 0.838
Elevated AST, % 4.8 14.3 11.9 5.4 19.4 14.3 0.573
  1. ALT alanine aminotransferase, AST aspartate aminotransferase
  2. a p value for the intergroup comparison of drug side effects