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Table 2 GlycA relationships with disease activity, inflammatory, and adiposity measures

From: A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls

  GlycA Fisher transformation
RA Controls P value
Markers of disease activity and inflammation
 Disability (HAQ-DI) 0.28 NA NA
 Pain (VAS) (mm) 0.08 0.11 0.91
 Disease activity (DASESR-28) 0.54 NA NA
 ESR (mm/hour) 0.71 0.24 0.02
 hsCRP (mg/l) 0.73 0.32 0.01
 IL-1β (pg/ml) 0.19 0.08 0.62
 IL-6 (pg/ml) 0.28 −0.14 0.05
 IL-8 (pg/ml) −0.20 −0.07 0.56
 IL-18 (pg/ml) −0.14 0.41 0.01
 TNFα (pg/ml) −0.09 −0.14 0.82
Measures of adiposity and insulin resistance
 BMI (kg/m2) 0.16 0.38 0.28
 Waist circumference (cm) 0.12 0.38 0.22
 Total abdominal adiposity (cm2) 0.31 0.36 0.80
 Abdominal subcutaneous adiposity (cm2) 0.26 0.34 0.70
 Abdominal visceral adiposity (cm2) 0.25 0.21 0.86
 Thigh subcutaneous adiposity (cm2) 0.21 0.55 0.08
 Thigh intermuscular adiposity (cm2) 0.06 0.18 0.60
 Thigh muscle density (Hu) −0.33 −0.14 0.40
 Fasting insulin (mU/l) 0.18 0.37 0.38
 Fasting glucose (mg/dl) 0.35 0.16 0.36
 HOMA 0.17 0.39 0.30
 IS index (×10–5.min−1/(pmol/l)) −0.26 −0.34 0.70
 Acute insulin response (pmol/l) 0.05 0.48 0.04
  1. Data presented as Spearman correlation coefficients (r)
  2. 0.005 < P <0.05, P ≤0.005
  3. BMI body mass index, DAS ESR -28 Disease Activity Score with 28-joint count using the erythrocyte sedimentation rate, ESR erythrocyte sedimentation rate, HAQ-DI Health Assessment Questionnaire–Disability Index, HOMA homeostasis model assessment, hsCRP high-sensitivity C-reactive protein, IL interleukin, IS insulin sensitivity, RA rheumatoid arthritis, TNFα tumor necrosis factor alpha, VAS visual analog scale, NA​ not applicable
  4. bold text represents significant associations