Skip to main content

Table 2 GlycA relationships with disease activity, inflammatory, and adiposity measures

From: A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls

 

GlycA

Fisher transformation

RA

Controls

P value

Markers of disease activity and inflammation

 Disability (HAQ-DI)

0.28

NA

NA

 Pain (VAS) (mm)

0.08

0.11

0.91

 Disease activity (DASESR-28)

0.54 ‡

NA

NA

 ESR (mm/hour)

0.71 ‡

0.24

0.02

 hsCRP (mg/l)

0.73 ‡

0.32 †

0.01

 IL-1β (pg/ml)

0.19

0.08

0.62

 IL-6 (pg/ml)

0.28 †

−0.14

0.05

 IL-8 (pg/ml)

−0.20

−0.07

0.56

 IL-18 (pg/ml)

−0.14

0.41 †

0.01

 TNFα (pg/ml)

−0.09

−0.14

0.82

Measures of adiposity and insulin resistance

 BMI (kg/m2)

0.16

0.38 †

0.28

 Waist circumference (cm)

0.12

0.38 †

0.22

 Total abdominal adiposity (cm2)

0.31 †

0.36 †

0.80

 Abdominal subcutaneous adiposity (cm2)

0.26

0.34 †

0.70

 Abdominal visceral adiposity (cm2)

0.25

0.21

0.86

 Thigh subcutaneous adiposity (cm2)

0.21

0.55 ‡

0.08

 Thigh intermuscular adiposity (cm2)

0.06

0.18

0.60

 Thigh muscle density (Hu)

−0.33 †

−0.14

0.40

 Fasting insulin (mU/l)

0.18

0.37 †

0.38

 Fasting glucose (mg/dl)

0.35 †

0.16

0.36

 HOMA

0.17

0.39 †

0.30

 IS index (×10–5.min−1/(pmol/l))

−0.26

−0.34 †

0.70

 Acute insulin response (pmol/l)

0.05

0.48 †

0.04

  1. Data presented as Spearman correlation coefficients (r)
  2. †0.005 < P <0.05, ‡ P ≤0.005
  3. BMI body mass index, DAS ESR -28 Disease Activity Score with 28-joint count using the erythrocyte sedimentation rate, ESR erythrocyte sedimentation rate, HAQ-DI Health Assessment Questionnaire–Disability Index, HOMA homeostasis model assessment, hsCRP high-sensitivity C-reactive protein, IL interleukin, IS insulin sensitivity, RA rheumatoid arthritis, TNFα tumor necrosis factor alpha, VAS visual analog scale, NA​ not applicable
  4. bold text represents significant associations