Fig. 4
From: Sjögren’s syndrome-associated microRNAs in CD14+ monocytes unveils targeted TGFβ signaling
SjS-associated miRNAs are predicted to target canonical TGFβ signaling network. a Summary of average pathway-coverage scores for the six SjS-associated miRNAs for TGFβ, MAPK, JAK-STAT, and TLR-NFκB signal transduction pathways. Bars represent mean percent coverage ± SD for the six miRNAs. ** P < 0.01 by one-way ANOVA with Bonferroni post tests. MiRNA target predictions for TGFβ (b), MAPK (c), JAK-STAT (d), and TLR-NFκB (e) were analyzed through databases for validated miRNA targets (black, direct evidence) and precomputed predicted miRNA targets (light gray, indirect evidence (weak) = 2 programs and dark gray, indirect evidence (strong) = 3 or more programs). f Visualization of predicted miRNA targeting of canonical TGFβ signal transduction pathway