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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: HM71224, a novel Bruton’s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

Fig. 2

Effect of HM71224 on Bruton’s tyrosine kinase (Btk) signaling. a The inhibitory effects of HM71224 on B cell receptor (BCR) signaling in the Ramos cell line. Ramos cells were stimulated with anti-IgM F(ab’)2 fragments in the presence of the indicated doses of HM71224. b Time-dependent restoration of Btk phosphorylation in Ramos cells after HM71224 washout. c Btk occupancy by HM71224 on Ramos cells. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. untreated control (crtl). ERK extracellular signal-regulated kinase

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