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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: HM71224, a novel Bruton’s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

Fig. 5

HM71224 inhibits osteoclastogenesis. a Representative images of osteoclastogenesis. Human CD14+ monocytes were cultured with the indicated concentrations of HM71224 during osteoclast differentiation (magnification × 100). b Dose-dependent inhibition of tartrate resistant alkaline phosphatase (TRAP)+ cells by HM71224. *P < 0.05 and **P < 0.01 vs. no treatment. MNGs is multinucleated giant cells

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