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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: CD163+ M2c-like macrophages predominate in renal biopsies from patients with lupus nephritis

Fig. 1

Distribution of macrophage subsets in different International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes. Total CD68+, M1-like inducible nitric oxide synthase (iNOS)+/CD68+ double-positive, M2a-like CD206+/CD68+ double-positive and M2c-like double-positive CD163+/CD68+ macrophages were analyzed in renal biopsies from patient with lupus nephritis ISN/RPS classes II–V using immunohistochemical analysis. a Total glomerular CD68+ macrophages. b Total tubulointerstitial CD68+ macrophages. c Glomerular M1-like macrophages. d Tubulointerstitial M1-like-macrophages. e Glomerular M2a-macrophages. f Tubulointerstitial M2a-like macrophages. g Glomerulular M2c-like macrophages. h Tubulointerstitial M2c-like macrophages. Significant differences between ISN/RPS classes are marked with lines and asterisks (*p < 0.05; **p < 0.01; ***p < 0.001)

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