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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: CD163+ M2c-like macrophages predominate in renal biopsies from patients with lupus nephritis

Fig. 7

Distribution of T regulatory cells and their correlation with macrophage subtypes. The number of forkhead box protein P3 (FoxP3) + regulatory T cells was analyzed in International Society of Nephrology/Renal Pathology Society (ISN/RPS) lupus classes and correlation tested with numbers of total CD68+, M1-like, M2a-like and M2c-like macrophages in the tubulointerstitium. a Glomerular FoxP3+ cells in ISN/RPS class II–V. b Tubulointerstitial FoxP3+ cells in ISN/RPS classs II–V. c Correlation between FoxP3+ cells and tubulointerstitial total CD68+ macrophages. d Correlation between FoxP3+ cells and tubulointerstitial M1-like macrophages. e Correlation between FoxP3+ cells and tubulointerstitial M2a-like macrophages. f Correlation between FoxP3+ cells and tubulointerstitial M2c-like macrophages. Significant differences and correlation are marked by asterisks (*p < 0.05; **p < 0.01)

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