Fig. 5

Frequency of topoisomerase-I-specific CD4+ T cells is associated with presence and progression of interstitial lung disease (ILD). a Frequency of topo-I reactive CD4+ T cells in anti-topo-I-positive SSc patients stratified by presence of ILD. Lines indicate means. P value was calculated using Wilcoxon rank-sum test. b Association of topo-I-specific CD4+ T cells with FVC (% predicted). c and d Associations between topo-I-specific CD4+ T cells frequency and the degree of ILD progression defined as % change in forced vital capacity (FVC) in the year preceding the test date (c) or in the subsequent 10 months (d) in those patients for whom follow-up data became available. Pearson correlation coefficient r and p values are displayed in b, c, and d