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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Impaired phagocytosis and reactive oxygen species production in phagocytes is associated with systemic vasculitis

Fig. 3

Disease activity in patients with anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is associated with decreased production of reactive oxygen species (ROS). ROS production was measured by flow cytometry after ex vivo activation of peripheral blood polymorphonuclear leukocytes (PMN) with phorbol 12-myristate 13-acetate (PMA) or opsonized E. coli in a patients with AAV in remission (Birmingham Vasculitis Activity Score version 3 (BVAS) = 0) or with some kind of disease activity (BVAS ≥1). b Patients are additionally divided based on prednisone treatment or not. The amount of ROS produced is shown as geometric mean fluorescence intensity (geoMFI). The two-sided Mann-Whitney test was used to calculate the level of significance between two groups and the Kruskal-Wallis test with Dunn’s multiple comparison test was used to calculate the level of significance between more than two groups. Line represents the median value of each dataset. HC healthy controls

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