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Table 2 Baseline chemokine levels in seropositive and seronegative RA patients. Values are presented as mean with standard deviation. P values were determined by Wilcoxon ranked sum test

From: Baseline CXCL10 and CXCL13 levels are predictive biomarkers for tumor necrosis factor inhibitor therapy in patients with moderate to severe rheumatoid arthritis: a pilot, prospective study

  IgM RF+ (n = 16) IgM RF- (n = 13) p value
CXCL10 (pg/ml) 510.2 ± 465.2 400.4 ± 525.3 0.16
CXCL13 (pg/ml) 371.6 ± 649.0 40.3 ± 55.6 0.02*
CCL20 (pg/ml) 9.7 ± 10.3 23.8 ± 30.5 0.09
  Anti-CCP+ (n = 15) Anti-CCP- (n = 14) p value
CXCL10 (pg/ml) 557.3 ± 458.0 357.8 ± 512.9 0.02*
CXCL13 (pg/ml) 396.6 ± 663.8 37.2 ± 54.4 0.005*
CCL20 (pg/ml) 9.6 ± 9.9 22.9 ± 29.7 0.12
  1. IgG immunoglobulin G, RF rheumatoid factor, CXCL10 C-X-C motif chemokine 10, CXCL13 C-X-C motif chemokine 13, CCL20 C-C motif chemokine 20, anti-CCP anti-cyclic citrullinated peptide
  2. *p < 0.05